Bovis ISSN 2398-2993

Pentobarbital

Synonym(s): Pentobarbital sodium,

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Pentobarbital sodium.

Class of drug

  • Barbiturate.

Description

Chemical name

  • 5-ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione.
  • 5-ethyl-5-(1-methylbutyl)barbituric acid.

Molecular formula

  • C11H18N2O3.

Physical properties

  • Non-sterile aqueous solution for injection.

Storage requirements

  • Protect from light.

Uses

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Indications

  • Euthanasia only.
  • Previously used as an IV anesthetic but has been superseded by other preparations.
  • Has been used as an anticonvulsant to treat acute seizures but has been superseded by other preparations.
    • May be considered as an anti-seizure drug when choice is limited by economics.
    • Use off-license in this way with care and ensure that you adhere to Cascade Cascade/local guidelines.

Administration

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Precautions

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Interactions

With other drugs

Sedatives 
  • Effects of Pentobarbital increased by concomitant administration of sedatives such as Xylazine Xylazine/Acepromazine Acepromazine etc.
Drugs which may interact to increase the effects of pentobarbital
  • Chloramphenicol.
  • Other central nervous system (CNS) depressants (antihistamines, narcotics, phenothiazines).
  • Valproic acid.
The effects of the following drugs may be decreased by Pentobarbital Pentobarbital (enhanced metabolism/decreased effect)
  • Beta-blockers, eg propranolol.
  • Corticosteroids.
  • Metronidazole Metronidazole.
  • Quinidine.
  • Theophylline.
Barbiturates
  • May enhance the effects of other anti-epileptics.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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