Bovis ISSN 2398-2993

Niclosamide

Synonym(s): Anthelmintic, salicylanilides

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Niclosamide.

Class of drug

  • Anthelmintic.
  • Salicylanilides.

Description

Chemical name

  • 5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide

Molecular formula

  • C13H8Cl2N2O4

Molecular weight

  • 327.120 Da

Physical properties

  • Bolus/ tablet.
  • Powder.
  • Oral solution.

Uses

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Indications

  • Indicated in the treatment of the cestode Moniezia expansa Thysanoma actinioides Tapeworm: overview. 
  • Indicated for the treatment of Paraphistomum species (Immature stages only) Paramphistome spp.
Not licensed for use in the UK.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Can be used concurrently with several other anthelmintics (such as Levamisole Levamisole) to treat mixed infections of Nematodes, Cestodes and Amphistomes.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Swan G E (1999) The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc 70(2), 61-70 PubMed.

Other sources of information

  • Spiderchem (2015) Niclosamide. Royal Society of Chemistry.
  • Veterinary Substances Database. Last updated 2018.General information for Niclosamide. University of Hertfordshire.
  • Specific product information for Niclosamide bolus (2014). Neospark Veterinary Pharmaceutical Formulations. 

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