ISSN 2398-2993      

Moxidectin

obovis

Introduction

Name

  • Moxidectin.

Class of drug

  • Macrocyclic lactone.
  • Semi-synthetic milbemycin.
  • Endectocide.

Description

Chemical name

  • (2aE,4E,8E)-(52S,6R,62S,11R,13R,15S,17aR,20R,20aR,20bS)-62-[(1E)-1,3-dimethylbut-1-enyl]-52,62,10,11,14,15,17a,20,20a,20b-decahydro-20,20b-dihydroxy-52,6,8,19-tetramethylspiro[11,15-methano-2H,13H,17H-furo[4,3,2-pq][2,6]benzodioxacyclooctadecin-13,22-[2H]pyran]-42,17(32H,6H)-dione 42-(E)-(O-methyloxime).

Molecular formula

  • C37H53NO8.

Molecular weight

  • 639.84.

Physical properties

  • Water Solubility (at 25 °C, pH 7): 51 ppb.
  • Octanol-water Partition Coefficient: 58.3. Therefore, it is highly lipophilic.
  • Photolysis half-life: 6.8 hours.
  • Finished product: pour on solution, injectable solution.

Storage requirements

  • In a cool environment (<25°C).
  • Protect from light.

Uses

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Indications

  • Moxidectin is an endectocide with activity against nematode and arthropod parasites.
  • The spectrum of activity is determined to some extent by the method of delivery.
  • Efficacy against mature and larval stages of many gastrointestinal nematode parasites of cattle.
  • Active against:
No action against trematodes, cestodes or protozoa.

Administration

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Pharmacokinetics

Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Yolande Bishop (ed) (2005) The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.
  • VMD product database.
  • Cydectin SPC.
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