Bovis ISSN 2398-2993

Meloxicam

Synonym(s): Non-Steroidal Anti-Inflammatory Drug (NSAID)

Contributor(s): Louise Cox-O’Shea, Andrea Tarr

Introduction

Name

  • Meloxicam.

Class of drug

  • Non-steroidal anti-inflammatory drug; COX-2 preferential.

Description

Chemical name

  • 4-hydroxy-2-methyl-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide.

Molecular formula

  • C14H13N3O4S2.

Molecular weight

  • 351.4 g.

Physical properties

  • Various strengths of formulation are available.
  • The color of solutions varies between maufacturers.
  • Some formulations contain benzyl alcohol.

Storage requirements

  • <25°C.
  • Solution for injection should be discarded after 28 days of opening.

Uses

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Indications

  • Meloxicam is used for the alleviation of inflammation and relief of pain.
  • In particular:
    • The treatment of acute respiratory infection (+/- suitable antibiotics).
    • The treatment of post operative pain eg dehorning.
Meloxicam will not be sufficient to control pain alone for surgical procedures such as dehorning. It should be used in conjunction with another suitable form of analgesia.
  •  For the treatment of diarrhea in calves (in conjunction with rehydration therapy).
  •  For the treatment of acute mastitis (in conjunction with suitable antibiotics).
There can be variations in the licensing of different medicines containing the same drug. Always check the specific product information for the preparation you are using.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Do not administer with other NSAIDs Anti-inflammatory drugs: overview or corticosteroids.
    • May compete for protein binding sites, leading to increased plasma concentrations of free drug and toxic effects. There are reported examples of highly protein bound drugs which may be displaced by NSAIDs such as oral anticoagulants, glucocorticoids, sulfonamides, valproic acid etc.
  • Concurrent administration of other nephrotoxic drugs should be avoided.
  • Avoid co-administration with anticoagulant drugs.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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