Bovis ISSN 2398-2993

Mannitol

Synonym(s): Osmotic diuretic

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Mannitol.

Class of drug

  • Osmotic diuretic.

Description

Molecular formula

  • C6H14O6.

Physical properties

  • Solution.

Uses

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Indications

  • To promote urine output.
  • Acute renal failure; to promote diuresis in the early stages of oliguric renal failure.
  • Cerebral trauma or edema.
  • Occular hypertension.
  • Not suitable for the mobilization of local or general edema as it may cause cardiac overload.
Not licensed for use in cattle

Administration

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Pharmocokinetics

Precautions

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Interactions

With other drugs

  • Mannitol may increase the nephrotoxic effect of aminoglycosides. Avoid concurrent use.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • The Veterinary Formulary 6th edition (2005) Yolande Bishop (Ed), Published in association with the British Veterinary Association.
  • Dill S G (1986) Polioencephalomalacia in Ruminants. In: Howard J L (ed) Current Veterinary Therapy: Food Animal Practice 2. Philadelphia: W.B. Saunders; pp 868-869.
  • Osweiler G D (1986) Nephrotoxic Plants. In: Howard J L (ed) Current Veterinary Therapy: Food Animal Practice 2. Philadelphia: W.B. Saunders; pp 401-404.
  • Diuretics. Patricia M. Dowling, DVM, MSc, DACVIM, DACVCP, Professor, Veterinary Clinical Pharmacology, Western College of Veterinary Medicine, University of Saskatchewan. MSD Merck Veterinary Manual. 
  • Plumb's Veterinary Drug Handbook.

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