Bovis ISSN 2398-2993

Levamisole

Synonym(s): Levamisole hydrochloride, anthelmintic

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Levamisole hydrochloride.

Class of drug

  • Imidazothiazole endoparasiticide.
  • Anthelmintic.
  • Immunostimulant.

Description

Chemical name

  • (S)-2,3,5,6-tetrahydro-6-phenylimidazo[2,1-b]thiazole.

Molecular formula

  • C11H12N2S.

Molecular weight

  • 204.

Physical properties

  • Clear yellow solution.
  • Dark blue solution (eg Levacide pour on)
  • Clear sterile solution.
  • Tablets.

Storage requirements

  • <25°C.
  • Protect from light.
  • In a dry environment.
  • Protect from freezing.

Uses

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Indications

  • Gastro-intestinal round worms.
  • Lungworms Lungworm.
  • Immunocompromise.
Immunocompromise: This indication is not authorised in the UK.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Do not use simultaneously or within 14 days before or after use with organophosphorous compounds or diethylcarbamazine.
  • Avoid using with chloramphenicol – fatalities reported.
  • Cholineterase-inhibiting drugs (eg organophosphate, neostigmine) could potentiate the adverse effects of levamisole.
  • Increased risk of bleeding with warfarin.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.

Organisation(s)


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