Bovis ISSN 2398-2993

Ivermectin

Synonym(s): Avermectin, endectocide, macrocyclic lactone.

Contributor(s): Louise Cox-O’Shea, Andrea Tarr, Vetstream Ltd

Introduction

Name

  • Ivermectin.

Class of drug

  • Avermectin, endectocide, macrocyclic lactone.

Description

Chemical name

  • Ivermectin is a mixture of ivermectin component H2B1a (5-O-demethyl-22,23-dihydroavermectin A1a; C48H74O14 = 875.1) and ivermectincomponent H2B1b (5-O-demethyl-25-de(1-methylpropyl)-25-(1-methylethyl)-22,23-dihydroavermectin A1a; C47H72O14 = 861.1).

Physical properties

  • Ivermectin is presented as a powder and is made up to a sterile non-aqueous solution. 
  • The formulations for cattle include: pour-on solutions and solution for injection.
  • Formulations are usually yellow or blue aqueous solutions.

Storage requirements

  • <25°C.
  • Protect from direct light.

Uses

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Indications

Endoparasites

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Do not combine Ivermectin treatment with vaccination against lungworms.
  • If vaccinated animals are to be treated, treatment should not be carried out within a period of 28 days before or after vaccination.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Yolande Bishop (2005) The Veterinary Formulary. 5th edn. Published in association with the British Veterinary Association.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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