Bovis ISSN 2398-2993
Furosemide
Synonym(s): Loop diuretic
Contributor(s): Louise Cox-O’Shea, Vetstream Ltd
, Andrea Tarr
Introduction
Name
Class of drug
Description
Chemical name
- 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid.
- 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.
Molecular formula
Physical properties
Storage requirements
- <25°C.
- Protect from light.
- Use or discard drug within 28 days of withdrawl of first dose.
Uses
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Indications
- Used to decrease edema in conditions such as:
- Cardiovascular and pulmonary edema.
- Hepatic and renal dysfunction.
- Hydrothorax.
- Ascites.
- Non-specific edema.
- Is a venodilator when administered as an IV injection.
Administration
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Pharmocokinetics
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Precautions
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Interactions
With other drugs
- The majority of drugs listed will not be used in general practice & may not be licensed, however may be used in hospital/ referral settings. Please check specific product information and comply with local rules.
- Acetazolamide - increased risk of hypokalemia with loop and thiazide diuretics.
- Aminoglycosides - enhanced ototoxicity with loop diuretics.
- Antidiabetic drugs - antagonism of hypoglycemic effect with loop and thiazide diuretics.
- Beta-adrenoceptor blocking drugs - increased risk of ventricular arrhythmias in the presence of hypokalemia.
- Cardiac glycosides - increased toxicity if hypokalemia occurs; enhanced effect of digoxin.
- Cephalosporins - increased risk of nephrotoxicity.
- Corticosteroids and corticotropin - antagonism of diuretic effect; increased risk of hypokalemia with loop and thiazide diuretics.
- Lidocaine - lidocaine effect antagonized by hypokalemia Hypokalemia syndrome with loop and thiazide diuretics.
- NSAIDs - antagonism of diuretic effect Anti-inflammatory drugs: overview.
- Estrogens - antagonism of diuretic effect.
- Quinidine - toxicity of quinidine is increased by hypokalemia with loop and thiazide diuretics.
- Sulfonamides - increased risk of sulfonamide allergy.
Withdrawal Period
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Adverse Reactions
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Further Reading
Publications
Refereed Papers
Other sources of information
- The Veterinary Formulary 6th edition (2005). Yolande Bishop (Ed), Published in association with the British Veterinary Association.
- NOAH compendium of datasheets.