Bovis ISSN 2398-2993

Furosemide

Synonym(s): Loop diuretic

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Furosemide.

Class of drug

  • Loop diuretic.

Description

Chemical name

  • 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoic acid.
  • 4-chloro-N-furfuryl-5-sulfamoylanthranilic acid.

Molecular formula

  • C12H11ClN2O5S.

Physical properties

  • Solution.

Storage requirements

  • <25°C.
  • Protect from light.
  •  Use or discard drug within 28 days of withdrawl of first dose.

Uses

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Indications

  • Used to decrease edema in conditions such as:
    • Cardiovascular and pulmonary edema.
    • Hepatic and renal dysfunction.
    • Hydrothorax.
    • Ascites.
    • Non-specific edema.
  • Is a venodilator when administered as an IV injection.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • The majority of drugs listed will not be used in general practice & may not be licensed, however may be used in hospital/ referral settings. Please check specific product information and comply with local rules.
    • Acetazolamide - increased risk of hypokalemia with loop and thiazide diuretics.
    • Aminoglycosides - enhanced ototoxicity with loop diuretics.
    • Antidiabetic drugs - antagonism of hypoglycemic effect with loop and thiazide diuretics.
    • Beta-adrenoceptor blocking drugs - increased risk of ventricular arrhythmias in the presence of hypokalemia.
    • Cardiac glycosides - increased toxicity if hypokalemia occurs; enhanced effect of digoxin.
    • Cephalosporins - increased risk of nephrotoxicity.
    • Corticosteroids and corticotropin - antagonism of diuretic effect; increased risk of hypokalemia with loop and thiazide diuretics.
    • Lidocaine - lidocaine effect antagonized by hypokalemia Hypokalemia syndrome with loop and thiazide diuretics.
    • NSAIDs - antagonism of diuretic effect Anti-inflammatory drugs: overview.
    • Estrogens - antagonism of diuretic effect.
    • Quinidine - toxicity of quinidine is increased by hypokalemia with loop and thiazide diuretics.
    • Sulfonamides - increased risk of sulfonamide allergy.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • The Veterinary Formulary 6th edition (2005). Yolande Bishop (Ed), Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.

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