Bovis ISSN 2398-2993

Florfenicol

Synonym(s): Fluorinated synthetic analogue of the antibiotic thiamphenicol

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Florfenicol amine.

Class of drug

  • Fluorinated synthetic analogue of the antibiotic thiamphenicol. 

Description

Chemical name

  • (1R,2S)-2-amino-3-fluoro-1-(4-methylsulfonylphenyl)propan-1-ol.

Molecular formula

  • C₁₂H₁₄Cl₂FNO₄S.

Molecular weight

  • 358.21 g/mol

Physical properties

  • Clear, colorless/ yellow/ straw coloured slightly viscous solution for injection.

Storage requirements

  • Check storage requirements for individual products.
  • Some products have no specific storage requirements.
  • Some require storage below 25°C and protection from freezing. 
  • Keep container in outer carton.
  • Use or discard within 28 days of withdrawal of first dose. 
  • Some products have a limit on the number of times the product can be broached; products should be prescribed/ dispensed accordingly.

Uses

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Indications

  • Florfenicol - sensitive infections.
  • Prevention & therapeutic treatment of respiratory tract infections caused by Florfenicol susceptible infections, eg Mannheimia haemolytica Mannheimia haemolytica, Mannheimia insomni, Pasteurella multocida Pasteurella multocida and Histophilus somni.
Not for use in cattle producing milk intended for human consumption. The off-label rule of seven days milk withhold does NOT apply to this drug.

Administration

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Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Pubchem, Open Chemistry Database (2017) Florfenicol amine. National Center for Biotechnology Information. PubChem Compound Database; CID=156406, https://pubchem.ncbi.nlm.nih.gov/compound/156406 (accessed Oct. 2, 2017).
  • Dairy UK (2017) Conditions of use for antibiotics kanamycin, cefquinome and florfenicol. Dairy UK: 6th floor, 201 High Holborn, London WCIV 7EP. www.dairyUK.org.
  • Yolande Bishop (Ed) (2005) The Veterinary Formulary 6th edition.  Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.

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