Bovis ISSN 2398-2993

Doxycycline

Contributor(s): Louise Cox-O’Shea, Paul Wood

Introduction

Name

  • Doxycycline.
At the time of publishing the authors know of only one licensed product containing doxycycline for use in UK cattle. The UK licensed product is only for use in pre-ruminant calves and is not licensed for use in adult cattle. Much of the information provided in this article below is not relevant to cattle and is included for interest only. Always check the specific product information and ensure that licensing rules are adhered to.

Class of drug

  • Lipid-soluble tetracycline antibiotic.

Description

Chemical name

  • (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide.

Molecular formula

  • C22H24N2O8.

Molecular weight

  • 444.4 g/mol.

Physical properties

  • Yellow crystalline powder.

Storage requirements

  • Store in dry cool place.
  • Avoid direct sunlight.
  • Store at room temperature, under 30°C/86°F.

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Meredith A (2015) Ed. Small Animal Formulary. Part B: Exotic Pets. 9th edn. BSAVA, UK. pp 195.
  • Johnson-Delaney C (2010) Guinea Pigs, Chinchillas, Degus and Duprasi. In: BSAVA Manual of Exotic Pets. 5th edn. Eds: Meredith A & Johnson-Delaney C. BSAVA, UK. pp 28–62.
  • Bishop Y (2005) The Veterinary Formulary. 6th edn. British Veterinary Association and Royal Pharmaceutical Society, UK.
  • Quesenberry K E & Carpenter J W (2004) Formulary. In: Ferrets, Rabbits and Rodents: Clinical Medicine and Surgery. 2nd edn. pp 436-444.
  • European Agency for the Evaluation of Medicinal Products (1997) Committee for Veterinary Medicinal Products. Doxycycline. Summary Report (2). Website: www.ema.europa.eu (pdf download).
  • Pubchem Doxycycline. NIH U.S. National Library of Medicine. National Center of biotechnology Information.
  • VMD (online) Suspected Adverse Reaction Surveillance Scheme (SARSS). Available at: www.vmd.defra.gov.uk.
  • NOAH (online) Adverse Reactions Reporting Forms. Available at: www.noahcompendium.co.uk.
  • VMD (online) Animal Adverse Reaction Reporting. Available at: www.vmd.defra.gov.uk.
  • FDA (online) FDA Adverse Event Reporting System (FAERS). Available at: www.fda.gov.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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