Bovis ISSN 2398-2993

Doxapram

Synonym(s): Respiratory stimulant

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Doxapram hydrochloride.

Class of drug

  • Respiratory stimulant.

Description

Chemical name

  • 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone.

Molecular formula

  • C₂₄H₃₀N₂O₂.

Molecular weight

  • 378.507.

Storage requirements

  • Drops:
    • Store in refrigerator between 2 & 8°C.
    • Protect from light.
    • Protect from freezing.
    • Use/discard product within 28 days of withdrawing first dose.
  •  Injection:
    • Store below 25°C.
    • Protect from light.
    • Protect from freezing.
    • Use/ discard product within 28 days of withdrawing first dose.
    • Any evidence of discoloration/ contamination - discard product.

Uses

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Indications

  • Respiratory stimulation of neonates.
  • Reversal of respiratory depression associated with overdose of general anesthesia, hypnotic drugs and sedatives.
Only licensed as respiratory stimulant for neonates in cattle.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Cyclopropane, enflurane, halothane, isoflurane and methoxyflurane - increased risk of cardiac arrhythmias.
  • Morphine - may induce convulsions.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2006) The Veterinary Formulary 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.

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