Bovis ISSN 2398-2993

Diminazene aceturate

Synonym(s): Protozoocide

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Diminazene aceturate.

Class of drug

  • Aromatic diamidine derivative.

Description

Chemical name

  • 2-acetamidoacetic acid;4-[2-(4-carbamimidoylphenyl)iminohydrazinyl]benzenecarboximidamide.

Molecular formula

  • C18H22N8O3.

Molecular weight

  • 398.427 g/mol.

Physical properties

  • Powder (sachets) to be reconstituted.
  • To reconstitute use 15mls sterile water for injection for each 2.36g sachet.
  • Ready to use injectable solution.

Storage requirements

  • Store below 30°C.
  • Ensure sachets are stored in a dry environment.
  • Reconstituted solution should be stored in a fridge and protected from light. Discard unused product after 15 days.
  • Injectable solution should be stored in a cool environment and protected from direct sunlight.

Uses

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Indications

  • Protozoocide.
  • Therapeutic and / or prophylactic treatment of Trypanosomosis Trypanosomosis caused by Trypanosoma congolense, T. vivax et T. brucei.
  • Therapeutic treatment of Babesiosis Babesiosis caused by Babesia bovis, & B. bigemina.
  • Theileriosis Theileriosis caused by Theileria annulata.
  • Mixed hemoprotozoal infections.
  • Pyrexia of unknown origin.
May not completely eradicate parasite.

Administration

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Pharmocokinetics

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Pub Chem (2017) Diminazene aceturate. Open chemistry database. US National library of medicine, National centre for biotechnology information.
  • Specific product information. Berenil Vet 7% RTU. MSD Animal Health.
  • Specific product information. Veriben. CEVA.

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