Bovis ISSN 2398-2993

Digoxin

Synonym(s): Cardiac gylcoside

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Digoxin.

Class of drug

  • Myocardial stimulant, cardiac glycoside.
At the time of publication there is no published Maximum Residue Limit (MRL) for Digoxin and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using digoxin in cattle or other animals destined for human consumption.

Description

Chemical name

  • (3-beta,5-beta,12-beta)-3-[(O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1 → 4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1 → 4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxycard-20(22)-enolide.

Molecular formula

  • C41H64O14.

Molecular weight

  • 780.9 g.

Physical properties

  • Tablets.
  • Solution.

Uses

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Indications

  • Congestive heart failure with systolic failure.
  • Supraventricular tachycardias.
At the time of publication there is no published Maximum Residue Limit (MRL) for Digoxin and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using digoxin in cattle or other animals destined for human consumption.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • There are many potential drug interactions with digoxin. The following is not a comprehensive list.
  • There is a narrow safety margin between the therapeutic and toxic concentrations of digoxin.
    • Calcium salts and Hemaccel - large doses of IV calcium can precipitate arrhythmias.
    • Muscle relaxants - arrhythmias with depolarizing muscle relaxants.
    • Quinidine - enhanced effect of digoxin through decreased renal clearance, volume of distribution and affinity of tissue receptors to digoxin.
    • Antacids, cimetidine, metoclopramide, oral neomycin, albuterol and penicillinamine may decrease digoxin absorption.
    • Diazepam, propafenone, omeprazole, quinidine, anticholinergics, succinycholine, verapamil, tetracycline, phenylbutazone and erythromycin may lead to increases in digoxin levels.
    • Drugs that decrease serum potassium may predispose to digoxin toxicity. They include diuretics, amphotericin B, corticosteroids, ACTH, some laxatives, glucagon, dextrose or dextrose/insulin infusion, and sodium polystyrene sulfonate.
At the time of publication there is no published Maximum Residue Limit (MRL) for Digoxin and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using digoxin in cattle or other animals destined for human consumption.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Koritz J D, Anderson K L, Neff-Davis C A, Wilcke J R & Davis L E (1983) Pharmacokinetics of digoxin in cattle. J Vet Pharmacol Ther 6(2), 141-147 PubMed.

Other sources of information

  • Commission Regulations (EU) No 37/2010 of 22 December 2009. On pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-5/reg_2010_37/reg_2010_37_en.pdf .
  • Yolande Bishop (Ed) (2005) The Veterinary Formulary 6th edition. Published in association with the British Veterinary Association. pp 239-240.
  • Plumb D C (2002) Veterinary Drug Handbook. 4th Edition. Published by Iowa State Press, Ames, Iowa, USA.

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