Bovis ISSN 2398-2993

Diazepam

Synonym(s): Valium, benzodiazepine, anti-epileptic

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Diazepam.

Class of drug

  • Benzodiazepine, anti-epileptic drug for status epilepticus.
At the time of publication there is no published Maximum Residue Limit (MRL) for Diazepam and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using diazepam in cattle or other animals destined for human consumption.

Description

Chemical name

  • 7-chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one.

Molecular formula

  • C16H13ClN2O

Molecular weight

  • 284.743 g/mol.

Physical properties

  • Tablets.
  • Solution/emulsion.

Uses

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Indications

At the time of publication there is no published Maximum Residue Limit (MRL) for Diazepam and therefore this drug should NOT be used in food producing animals. The information given below is for interest only and Vetstream advise against using diazepam in cattle or other animals destined for human consumption.
  • Has been used as a pre-med and as an induction agent (eg with Ketamine) in cattle.
  • Muscle relaxant.
  • Treatment of seizures. 

Administration

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Precautions

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Interactions

With other drugs

  • Phenobarbital - potentiated effect with diazepam and may precipitate respiratory and cardiovascular collapse. 
  • Cimetidine Cimetidine - increased plasma-diazepam concentration.
  • Phenytoin - increased or reduced phenytoin metabolism.

Withdrawal Period

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Pub Chem. Open chemistry database. Modified 2017. Diazepam. U.S. National Library of Medicine, National Centre for Biotechnology Information.
  • Commission Regulations (EU) No 37/2010 of 22 December 2009. On pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin: https://ec.europa.eu/health/sites/health/files/files/eudralex/vol-5/reg_2010_37/reg_2010_37_en.pdf
  • Yolande Bishop (Ed) (2005) The Veterinary Formulary. 6th edition. Published in association with the British Veterinary Association, p 293.
  • University of Pennsylvania (2003) Complete list of drugs. Extralabel drug doses and withholding times in cattle.

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