Bovis ISSN 2398-2993

Dexamethasone

Synonym(s): Glucocorticoid

Contributor(s): Louise Cox-O’Shea, Andrea Tarr

Introduction

Name

  • Dexamethasone.

Class of drug

  • Corticosteroid, glucocorticoid.

Description

Chemical name

  • (11-beta,16-alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione.

Molecular formula

  • C22H29FO5.

Physical properties

  • Colorless, sterile, aqueous solution for injection.
  • Tablets (licensed for humans).
  • Oral formulations (powder, bolus) licensed for veterinary use in some countries.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

  • Shock.
Early administration of a large IV dose may be beneficial in circulatory failure or shock irrespective of the cause, but evidence for this is limited..

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  •  Do not use with NSAIDs; increased risk of gastrointestinal ulceration if used concurrently.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers


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