Bovis ISSN 2398-2993

Detomidine hydrochloride

Contributor(s): Kate White , Andrea Tarr

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Introduction

Name

  • Detomidine hydrochloride.

Class of drug

  • Alpha-2 adrenoceptor stimulant.

Description

Chemical name

  • 4-(2,3-Dimethylbenzyl)imidazole hydrochloride.

Molecular formula

  • C12H14N2,HCl.

Molecular weight

  • 222.7.

Physical properties

  • Available as solution for injection

Storage requirements

  • Store at room temperature. Protect from light.

Uses

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Indications

  • Sedation (duration of sedation is likely to be longer, more predictable and result in less ataxia compared to xylazine Xylazine, and may cause less of an effect on the gravid uterus of pregnant cattle).
  • Prior to ketamine Ketamine hydrochloride for general anesthesia.

Administration

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Precautions

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Interactions

With other drugs

  • Effects additive with other alpha-adrenoceptor stimulants (eg xylazine Xylazine).
  • SPCs/datasheets warn against use with intravenous potentiated sulfonamides as fatal dysrhythmias may occur.
  • Not be used in combination with sympathomimetic amines such as adrenaline, dobutamine and ephedrine. 
  • Severe hypotension can result from concurrent use with phenothiazines (eg acepromazine Acepromazine).

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Alexander D (2014) The bovine caesarean - part two, difficult caesareans (potential pitfalls and how to overcome them). In Practice, (36), 15–26.
  • Hokkanen A H, Raekallio M R, Salla K, Viitasaari E, Norring M & Vainio O M (2014) Sublingual administration of detomidine to calves prior to disbudding: A comparison with the intravenous route. Veterinary Anaesthesia and Analgesia, 41 (4), 372–377 PubMed.
  • Abrahamsen E J (2013) Chemical restraint and injectable anesthesia of ruminants. The Veterinary Clinics of North America. Food Animal Practice, 29 (1), 209–27 PubMed.
  • Alexander D (2013) Bovine caesarean section 1. On-farm operations. In Practice, 35 (10), 574–588 VetMedResource.
  • Hallowell G, Potter T & Aldridge B (2012) Medical support for cattle and small ruminant surgical patients. In Practice, 34 (4), 226–233 VetMedResource.
  • Lin H C & Riddell M G (2003) Preliminary study of the effects of xylazine or detomidine with or without butorphanol for standing sedation in dairy cattle. Veterinary Therapeutics : Research in Applied Veterinary Medicine, 4 (3), 285–291 VetMedResource.
  • Jedruch J & Gajewski Z (1986) The effect of detomidine hydrochloride (Domosedan) on the electrical activity of  the uterus in cows. Acta Veterinaria Scandinavica. Supplementum, 82, 189–192 PubMed.

Other sources of information

  • Plumb's Veterinary Drugs.
  • VMD Product Database.

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