Bovis ISSN 2398-2993

Cloxacillin

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Cloxacillin.

Class of drug

  • Beta-lactamase-resistant beta-lactam antibiotic.

Description

Molecular formula

  • C19H18ClN3O5S

Molecular weight

  • 435.88 g/mol.

Storage requirements

  • Store at temperatures below 25°C.
  • Use or discard opthalmic ointment within 28 days of withdrawing first dose.
  • Intramammary tubes to be used once - any unused product should be disposed of.

Uses

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Indications

  •  Bacterial eye infections: treatment of infection caused by beta-lactamase producing Staphylococcus spp Staphylococcus spp , Bacillus spp and Moraxella spp  Moraxella bovis.
  • Intramammary preparation. Licensed for use in cattle to treat mastitis.
    • Active against : Streptococcus agalactiae Streptococcus agalactiae mastitis (and other Streptococcal spp Streptococcus spp), Actinomyces pyogenes, Staphyloccal spp (penicillin resistant/ sensitive).
    • Some intramammary formulations also contain ampicillin Ampicillin to extend the antibacterial spectrum.

Administration

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Precautions

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Interactions

With other drugs

  •  May interact with other bacteriostatic antibiotics, eg:

Withdrawal Period

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Yolande Bishop (2005) The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.
  • VMD product database.

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