Bovis ISSN 2398-2993

Closantel

Synonym(s): Closantel sodium dihydrate, anthelmintic

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Closantel.
  • Usually available as Closantel sodium dihydrate .

Class of drug

  • Anthelmintic.
  • Endectocide.
  • Flukicide.
  • Salicylanilides.

Description

Chemical name

  • N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide

Molecular formula

  • C22H14Cl2I2N2O2

Molecular weight

  • 663.074 Da

Physical properties

  • Solution for injection, pour on and oral solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Gastrointestinal roundworms

  • Ostertagia ostertagi (including inhibited larval stages) Ostertagia ostertagi.
  • Ostertagia lyrata (adult).
  • Haemonchus placei (immature and adult) Haemonchus placei.
  • Trichostrongylus axei (immature and adult) Trichostrongylus axei. 
  • Trichostrongylus colubriformis (immature and adult).
  • Cooperia oncophora (immature and adult) Cooperia spp.
  • Cooperia punctata (immature and adult).
  • Cooperia pectinata (immature and adult).
  • Oesophagostomum radiatum (immature and adult) Oesophagostomum.
  • Nematodirus helvetianus (adult) Nematodirus spp.
  • Nematodirus spathiger (adult).
  • Strongyloides papillosus (adult) Strongyloides spp.
  • Bunostomum phlebotomum (immature and adult) Bunostomum spp.
  • Toxocara vitulorum (adult).
  • Trichuris spp Trichuris spp.

Lungworms

Liver Fluke (trematodes) (mature and late imature)

Eyeworms (adult)

Lice Pediculosis

  • Linognathus vituli.
  • Haematopinus eurysternus.
  • Solenopotes capillatus.
  • Mange mites Mites (burrowing and non-burrowing).
  • Psoroptes ovis (syn P communis var bovis).
  • Sarcoptes scabiei var bovis.
  • Can be used in the control of the biting louse Damalinia bovis and the mange mite Chorioptes bovis, but complete elimination may not occur.
Check the specific product information for indications. There may be differences between products, including different methods of application.

Administration

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Pharmocokinetics

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Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMed Resource.
  • Swan G E (1999) The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc 70(2), 61-70 PubMed.

Other sources of information

  • Spiderchem (2015) Closantel. Royal Society of Chemistry.
  • Specific product information sheets. Closamectin solution for injection for cattle and sheep. Norbrook.
  • Specific product information sheets. Closamectin pour on. Norbrook.
  • Pub Chem. Open chemistry database. Modified 2018. Closantel. U.S. National Library of Medicine, National Centre for Biotechnology Information.
  • Parasitipedia.net. Closantel.
  • Veterinary Medicines Directorate. Product Database.

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