Bovis ISSN 2398-2993

Closantel

Synonym(s): Closantel sodium dihydrate, Anthelmintic

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Closantel.
  • Usually available as Closantel sodium dihydrate.

Class of drug

  • Anthelmintic.
  • Endectocide.
  • Flukicide.
  • Salicylanilides.

Description

Chemical name

  • N-(5-chloro-4-((4-chlorophenyl)(cyano)methyl)-2-methylphenyl)-2-hydroxy-3,5-diiodobenzamide.

Molecular formula

  • C22H14Cl2I2N2O2.

Molecular weight

  • 663.074 Da.

Physical properties

  • Solution for injection, pour on and oral solution.

Storage requirements

  • <25°C.
  • Protect from light.

Uses

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Indications

Gastrointestinal roundworms

  • Ostertagia ostertagi (including inhibited larval stages) Ostertagia ostertagi.
  • Ostertagia lyrata (adult).
  • Haemonchus placei (immature and adult) Haemonchus placei.
  • Trichostrongylus axei (immature and adult) Trichostrongylus axei. 
  • Trichostrongylus colubriformis (immature and adult).
  • Cooperia oncophora (immature and adult) Cooperia spp.
  • Cooperia punctata (immature and adult).
  • Cooperia pectinata (immature and adult).
  • Oesophagostomum radiatum (immature and adult) Oesophagostomum.
  • Nematodirus helvetianus (adult) Nematodirus spp.
  • Nematodirus spathiger (adult).
  • Strongyloides papillosus (adult) Strongyloides spp.
  • Bunostomum phlebotomum (immature and adult) Bunostomum spp.
  • Toxocara vitulorum (adult).
  • Trichuris spp Trichuris spp.

Lungworms

Liver Fluke (trematodes) (mature and late immature)

Eyeworms (adult)

Lice Pediculosis

  • Linognathus vituli.
  • Haematopinus eurysternus.
  • Solenopotes capillatus.
  • Mange mites Mites (burrowing and non-burrowing).
  • Psoroptes ovis (syn P communis var bovis).
  • Sarcoptes scabiei var bovis.
  • Can be used in the control of the biting louse Damalinia bovis and the mange mite Chorioptes bovis, but complete elimination may not occur.
Check the specific product information for indications. There may be differences between products, including different methods of application.

Administration

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Precautions

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Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMed Resource.
  • Swan G E (1999) The pharmacology of halogenated salicylanilides and their anthelmintic use in animals. J S Afr Vet Assoc 70 (2), 61-70 PubMed.

Other sources of information

  • NOAH & VMD (2020) Joint Statement from the National Office of Animal Health (NOAH) and the Veterinary Medicines Directorate (VMD) on the Use of Flukicides in Dairy Cattle. Website: www.noah.co.uk (pdf download).
  • Norbrook (online) Closamectin Injection. Closamectin solution for injection for cattle and sheep. Website: www.norbrook.com.
  • Norbrook (online) Closamectin Pour-On. Website: www.noorbrook.com.
  • PubChem (online) Closantel. In: National Library of Medicine, National Centre for Biotechnology Information. Website: https://pubchem.ncbi.nlm.nih.gov.
  • Parasitipedia (online) Closantel: Safety Summary for Veterinary Use. Website: https://parasitipedia.net.
  • Veterinary Medicines Directorate (online) Product Database. Website: www.vmd.defra.gov.uk.

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