ISSN 2398-2993      

Clindamycin

obovis
Contributor(s):

Synonym(s): Lincosamide antibiotic


Introduction

Name

  • Clindamycin.

Class of drug

  • Lincosamide antibiotic.

Description

Chemical name

  • (2S-trans)-methyl 7-chloro-6,7,8-trideoxy-6-[[(1-methyl-4-propyl-2-pyrrolidinyl)carbonyl]amino]-1-thio-L-threo-alpha-D-galacto-octopyranoside.

Molecular formula

  • C18H22ClN2O5S.

Molecular weight

  • 425.

Storage requirements

  • <25°C.
Contraindicated in ruminants: may cause severe/ fatal GI effects.

Uses

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Indications

Contraindicated in ruminants: may cause severe/fatal GI effects.

Administration

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Pharmacokinetics

Precautions

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Interactions

With other drugs

  • Cross-resistance:
    • Complete cross-resistance between lincomycin Lincomycin and clindamycin.
  • Partial cross-resistance with erythromycin:
    • Non-depolarizing muscle relaxants, eg tubocurarine
    • May be increased by clindamycin, which has neuromuscular blocking activity.
  • Neostigmine and pyridostigmine:
    • May by antagonised by clindamycin.
  • Erythromycin Erythromycin:
    • Antagonize each other's effects in vitro; clinical significance unknown.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2006) The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.
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