Bovis ISSN 2398-2993

Cimetidine

Synonym(s): H2 histamine receptor antagonist

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Cimetidine.
Not licensed for use in cattle in the UK

Class of drug

  • Anti-ulcer medication.
  • H2 histamine receptor antagonist.

Description

Chemical name

  • N-cyano-N'-methyl-N"-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine.

Molecular formula

  • C10H16N6S.

Physical properties

  • Tablets.
  • Oral suspension.
  • Injection.

Uses

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Indications

Administration

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Precautions

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Interactions

With other drugs

  • Beta-adrenoceptor blocking drugs, Diazepam Diazepam, fluorouracil, Metronidazole Metronidazole, Opioids Opioids, quinidine, theophylline - increased plasma concentration of interacting drug.
  • Ketoconazole - reduced ketoconazole absorption.
  • Lidocaine Lidocaine - increased risk of lidocaine toxicity.
  • Phenytoin - reduced phenytoin metabolism.
  • Warfarin - enhanced anticoagulant effect.

Withdrawal Period

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMed Resource.
  • Ahmed F, Ahmed M S, Peter D et al (2001) Effect of orally administered cimetidine and ranitidine on abomasal luminal pH in clinically normal milk-fed calves. American Journal of Veterinary Research 62 (10) pp 1531-1538.

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2. pp 188 & 209.
  • Peter D Constable BVSc (Hons) MS PhD DACVIM Dean College of Veterinary Medicine, University of Illinois. Abomasal ulcers. MSD Veterinary Manual.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.

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