Bovis ISSN 2398-2993

Chlorphenamine

Synonym(s): chlorpheniramine, antihistamine

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Chlorphenamine.

Class of drug

  • H1 antihistamine.

Description

Chemical name

  • Gamma-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine.
  • 2-[p-chloro-alpha-(2-dimethylaminoethyl)benzyl]pyridine.

Molecular formula

  • C16H19ClN2.

Molecular weight

  • 274.788.

Physical properties

  • Odorless, white, crystalline powder. Soluble in water and alcohol.
  • 1 g soluble in 4 ml water.
  • Oily liquid.
  • Tablets.

Storage requirements

  • Store in tight and well-closed containers, at room temperature.
  • Injectable preparations should be stored in light-resistant containers.

Uses

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Indications

  • Allergies.
  • Anaphylactic reactions. Anaphylaxis and urticaria
  • Commonly used in companion animals as premedication before transfusions and certain chemotherapeutic agents.
  • May reduce pruritus in some conditions.  Photosensitization
  • In cattle; may be used in conjunction with antimicrobials (& less commonly corticosteroids) in the treatment of respiratory diseases.
  • Weak sedative.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • CNS depressant drugs.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Yolande Bishop (ed) (2005) The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
  • The European agency for the evaluation of medicinal products (1999) Committee for medicinal products; chlorphenamine. Summary report.
  • Neocell pharmaceuticals [online]. Veterinary medicines for large animals -ancesol 10mg/ml. Website: www.neocell.gr. Last accessed 15th March 2018.
  • Richter pharma ag [online]. Overview Richter pharma products: ancesol. Website: www.ritcher-pharma.ag. Last accessed 15th March 2018.
  • Veterinary medicines directorate [online]. VMD product database. Website: www.vmd.defra.gov.uk. Last accessed 15th March 2018.

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