Bovis ISSN 2398-2993

Cefquinome

Synonym(s): Cephalosporin (4th generation)

Contributor(s): Louise Cox-O’Shea, Vetstream Ltd , Andrea Tarr

Introduction

Name

  • Cefquinome.

Class of drug

  • Cephalosporin (4th generation).

Description

Molecular formula

  • C23H24N6O5S2.

Molecular weight

  • 528.60 g/mol.

Physical properties

  • Oily injectable solution.
  • Powder & solvent for solution for injection.
  • Intramammary (suspension) tubes.

Storage requirements

  • Dry Cow Intramammary tubes: no special storage requirements.
  • Milking cow intramammary tubes: store at temperatures below 25 or 30°C (varies between products).
  • Powder and solution: no special storage requirements. Once reconstituted store in a refrigerator between 2- 8°C and use/ discard within 10 days.
  • For reconstituted solution and suspension swab septum before withdrawing each dose.
  • Intramammary suspension: store at temperatures below 25°C. Protect from light.

Uses

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Indications

  • Gram negative and gram positive organisms sensitive to Cefquinome.
  • Dry cow Intramammary tubes: sub clinical mastitis at the drying off period.
  • Dry cow Intramammary tubes: prevention of new (Cefquinome sensitive) bacterial infections in the drying off period.
  • Milking cow intramammary tubes: treatment of clinical mastitis caused, by cefquinome sensitive organisms, in lactating cows.
  • Injectable suspension and solution: cows: respiratory diseases caused by Pasturella multocida Pasturella multocida & Mannheimia haemolytica Mannheimia haemolytica. Digital dermatitis Digital dermatitis, infectious bulbar necrosis and acute interdigital necrobacillus. Acute E.coli mastitis with systemic involvement E. coli mastitis.
  • Injectable suspension and solution: calves: E. coli Septicemia. E. coli

 There are many different products that contain Cefquinome and they are licenced for a variety of purposes. The withdrawal periods vary significantly between products and so the specifuc product information should always be checked.

Administration

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Precautions

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Interactions

With other drugs

  • Due to lack of clinical trials it is advised not to use Cefquinome products with other veterinary medicines unless specifically stated.
  • Do not use concurrently with bacteriostatic medications.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.

Organisation(s)

  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • Responsible Use of Medicines in Agriculture Alliance: RUMA.  https://www.ruma.org.uk

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