Bovis ISSN 2398-2993

Buparvaquone

Synonym(s): Antiprotozoal

Contributor(s): Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Buparvaquone.

Class of drug

  • Hydroxynaphthoquinone antiprotozoal drug.

Description

Chemical name

  • 3-[(4-tert-butylcyclohexyl)methyl]-4-hydroxynaphthalene-1,2-dione.

Molecular formula

  • C21H26O3.

Molecular weight

  • 326.435 g/mol.

Physical properties

  • Solution for injection.
  • Clear, ruby coloured.

Storage requirements

  • Store below 25°C.
  • Protect from light.
  • Protect from freezing/ frost.

Uses

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Indications

  • Treatment of Theileriosis Theileriosis in cattle. (East coast fever, tropical Theileriosis, corridor disease, January disease.
  • Active against T.annulata, T.orientalis(seargenti) & T. parva.
  • For the treatment of clinically affected animals and asymptomatic in- contact animals.
  • Can be used in the incubation period.
  • Active against Theileria species at the schizont and piroplasm stages.

Administration

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Pharmocokinetics

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Precautions

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Interactions

With other drugs

  • Avoid vaccination in clinical cases: Theileriosis severely depresses the immune system.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMed Resource.
  •  McDougall S 1, Hillerton J E 2 & Pegram D 3 (2016) Concentrations of buparvaquone in milk and tissue of dairy cows. N Z Vet J 64 (6) pp 318-23.

Other sources of information

  • National Center for Biotechnology Information (2017) Buparvaquone. [online] Available at: https://pubchem.ncbi.
  • Coopers K- Brands Ltd (2013) Anti-infectives: Butalex. [online] Available at: http://coopers.co.ke.
  • Bishop Y (2005) Ed The Veterinary Formulary. 6th edn. Pharmaceutical Press. ISBN: 0-85369-579-2.
  • McHardy N (1989) Buparvaquone, the new antitheilerial: A review of its efficacy and safety. [online] Available at: http://www.fao.org/.

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