Bovis ISSN 2398-2993

Ampicillin

Contributor(s): Vetstream Ltd, Louise Cox-O’Shea , Andrea Tarr

Introduction

Name

  • Ampicillin.

Class of drug

  • Beta-lactam antibacterial, broad-spectrum penicillin.

Description

Chemical name

  • [2S-[2-alpha,5-alpha,6-beta(S*)]]-6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.

Molecular formula

  • C16H19N3O4S.

Physical properties

  • Sterile, non-aqueous suspension.
  • Clear yellow aqueous solution.
  • Also available as white tablets, oral suspension and red and gray capsules- but not suitable for, or licensed for use in cattle.

Storage requirements

  • <25°C.
  • Store tablets in a dry environment.
  • Do not store in freezer.
  • Can be stored in fridge (at 2-8°C).

Uses

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Indications

  • Ampicillin-sensitive infections.
  • This includes a range of Gram-positive, Gram-negative and anerobic organisms.

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • A synergistic effect is usually described in-vitro with the aminoglycosides. 
  • Bacteriostatic antimicrobials may reduce the efficacy of ampicillin.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

Other sources of information

  • Yolande Bishop (2005) The Veterinary Formulary. 6th edn. Published in association with the British Veterinary Association.
  • NOAH compendium of datasheets.
  • VMD Product Database.

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