Bovis ISSN 2398-2993

Albendazole

Synonym(s): Abendazolum

Contributor(s): Louise Cox-O’Shea, Andrea Tarr

Introduction

Name

  • Albendazole.

Class of drug

  • Broad spectrum anthelmintic.
  • Benzimidazole antiparasitic agent.

Description

Chemical name

  • Methyl 5-(propylthio)-2-benzimidazolecarbamate.

Molecular formula

  • C12H15N3O2S.

Molecular weight

  • 265.34.

Physical properties

  • White powder insoluble in water and soluble in dimethyl sulfoxide, strong acids, strong bases and slightly soluble in alcohol.

Storage requirements

  • Albendazole suspension should be stored at room temperature.
  • Avoid freezing.
  • Shake well before using.

Uses

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Indications

Administration

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Precautions

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Interactions

With other drugs

  • Dexamethasone Dexamethasone, praziquantel Praziquantel and cimetidine Cimetidine may increase serum levels of albendazole.
  • Albendazole may affect theophylline metabolism. In the unlikely event that a bovine patient is to be treated with concurrent albendazole and theophylline preparations then advice should be sought from product manufacturers prior to treatment.
  • Concurrent use of other ruminal boluses contraindicated.
  • Not to be diluted with or mixed with other drugs.

With diagnostic tests

  • Monitor efficacy and adverse effect while treating patients with albendazole.
  • Consider monitoring complete blood count (CBC) and liver parameters if treated long-term.

With diagnostic tests

  • Monitor efficacy and adverse effect while treating patients with albendazole.
  • Consider monitoring complete blood count (CBC) and liver parameters if treated long-term.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Prichard R K, Hennessy D R, Steel J W & Lacey E (1985) Metabolite concentrations in plasma following treatment of cattle with five anthelmintics. Res vet Sci 39 (2), 173-178 PubMed.

Other sources of information

  • NOAH & VMD (2020) Joint Statement from the National Office of Animal Health (NOAH) and the Veterinary Medicines Directorate (VMD) on the Use of Flukicides in Dairy Cattle. Website: www.noah.co.uk (pdf download).
  • NOAH (2015) Compendium of Data Sheet for Animal Medicines. pp 106-107, 265-266, 1048, 1050. Website: www.noahcompendium.co.uk.
  • Plumb D C (2015) Plumb's Veterinary Drug Handbook. 8th edn. Blackwell Publishing, USA. pp 1296. Website: www.plumbsveterinarydrugs.com.
  • Bishop Y (2004) The Veterinary Formulary. 6th edn. Pharmaceutical Press, UK. pp 190.
  • FDA (online) FDA Adverse Event Reporting System (FAERS). Available at: www.fda.gov.
  • NOAH (online) Adverse Reactions Reporting Forms. Available at: www.noahcompendium.co.uk.
  • VMD (online) Animal Adverse Reaction Reporting. Available at: www.vmd.defra.gov.uk.
  • VMD (online) Suspected Adverse Reaction Surveillance Scheme (SARSS). Available at: www.vmd.defra.gov.uk.

Organisation(s)

  • Veterinary Medicines Directorate (VMD) Product Information Database. Website: www.vmd.defra.gov.uk.

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