Bovis ISSN 2398-2993

Familial acantholysis

Synonym(s): Erosions, ulcerations, inherited

Contributor(s): Catherine Fraser , Ben Dustan

Introduction

  • Cause: inherited.
  • Signs: erosions and ulcerations.
  • Diagnosis: histopathology.
  • Treatment: none.
  • Prognosis: grave.

Pathogenesis

Etiology

  • Probably an autosomal recessive inherited trait in Angus calves.

Pathophysiology

  • Defective collagen bridging in deep dermal layers with abnormal development of desmosomes and tonofilaments.
  • Leads to acantholysis and skin loss.

Timecourse

  • Affected calves do not survive.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Hill F (2003) A triad of bovine inherited diseases. NZ Vet Med J 51 (1) 46 PubMed.
  • Jolly R D et al (1973) Familial Acantholysis of Angus calves. Vet Pathol 10, 473 PubMed.

Other sources of information

  • Scott D W (1988) Large Animal Dermatology. W B Saunders. Philadelphia.


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