This article is available in full to registered subscribers Sign up now for a 30 day trial or log in Name Mannitol. Class of drug Osmotic diuretic. Uses Action Water retained in nephron → diluted urinary sodium → reduced reabsorption in Loop of Henle. Indications To promote urine output. Acute renal failure . Cerebral trauma or edema. Administration Sign up to view the full article or log in Precautions Sign up to view the full article or log in Adverse reactions Other reported reactions Cardiac overload. Severe hypovolemia → give electrolytes to maintain extracellular fluid volume . Extravasation → inflammation and thrombophlebitis.