Lapis ISSN 2398-2969

Methylprednisolone

Contributor(s): Anna Meredith

Introduction

Name

  • Methylprednisolone.

Class of drug

Uses

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Indications

  • Anti-inflammatory suitable for alternate day use.
  • Treatment for shock.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

Amphotericin B or potassium-depleting diuretics (Frusemide, thiazides)

Insulin

  • Insulin requirements are likely to increase.

Phenobarbitone or phenytoin

  • The metabolism of corticosteroids may be enhanced.
  • Increased risk of gastrointestinal ulceration if used concurrently with NSAIDs.

with diagnostic tests

  • May increase urine glucose levels.
  • May decrease serum T3 and T4 values.
  • Will increase steroid induced alkaline phosphatase in dogs.
  • Some cross reaction with cortisol assay. May interfere with interpretation of other tests eg ACTH stimulation test.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.

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