Lapis ISSN 2398-2969

Ketamine

Contributor(s): Molly Varga, John Dodam, Jill Pearson

Introduction

Name

  • Ketamine.

Class of drug

  • Cyclohexanone derivative.
  • N-methyl-D-aspartate (NMDA) receptor antagonist.

Description

Chemical name

  • (+/-)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone.

Molecular formula

  • C13H16ClNO.

Molecular weight

  • 237.73.

Physical properties

  • White crystals.

Storage requirements

  • In a locked cabinet.
  • <25%.
  • Protect from light.

Uses

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Indications

  • A dissociative anesthetic/analgesic used to provide restraint or dissociative anesthesia.
  • Dissociative anesthesia is associated with mild stimulation of cardiac output and blood pressure, modest respiratory depression and preservation of cranial nerve reflexes.

Eyes remain open during anesthesia, thus a bland ophthalmic lubricant should be used.

  • Useful in reptiles, particularly those who 'breath hold'.

Administration

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Pharmacokinetics

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Precautions

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Adverse Reactions

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Orr H E, Roughan J V & Flecknell P A (2005) Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit. Vet Anaesth Analg 32 (5), 271-279 PubMed.
  • González Gil A, Illera J C, Silván G et al (2001) Plasma glucocorticoid concentrations after fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anaesthesia in New Zealand white rabbits. Vet Rec 148 (25), 784-786 PubMed.

Other sources of information

Organisation(s)


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