Lapis ISSN 2398-2969

Amikacin

Contributor(s): Anna Meredith

Introduction

Name

  • Amikacin.

Class of drug

  • Aminoglycoside antibiotic.

Uses

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Indications

  • Pseudomonas aeruginosainfections.
  • Gentamicin-resistant infections   Gentamicin  .
  • Probable gentamicin-resistant, gram-negative infections.

Administration

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Pharmacokinetics

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Precautions

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Interactions

with other drugs

  • Avoid the concurrent use of other nephrotoxic, ototoxic or neurotoxic agents, eg amphotericin B, cisplatin, frusemide, methoxyflurane. Increase monitoring and adjust dosages when these drugs must be used with amikacin.
  • Aminoglycosides may be inactivated by beta-lactam antibiotics, eg penicillins, cephalosporins or heparin when mixedin vitro. This may present a problemin vivoin patients who have substantially diminished renal function.
  • The effect of non-depolarizing muscle relaxants, eg atracurium, pancuronium, tubocuramine, vecuronium, may be enhanced by aminoglycosides.
  • Synergism may occur when aminoglycosides are used with penicillins or cephalosporins (Streptococcus faecalis) or with ticarcillin (Pseudomonas aeruginosa).

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Based on Small Animal Formulary. Tennant Bryn (1999) 3rd edn. Cheltenham: BSAVA.
  • The Veterinary Formulary. 4th edn (1998) Bishop Y (ed). British Veterinary Association and Royal Pharmaceutical Society.
  • Carpenter (1996) Exotic Animal Formulary. 1st edn. Greystone Publications.

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