Felis ISSN 2398-2950

Low-dose dexamethasone suppression test

Synonym(s): LDDST

Contributor(s): David Bruyette, Carmel Mooney, Yvonne McGrotty

Overview

  • Administration of exogenous glucocorticoid (dexamethasone) suppresses hypothalamic-pituitary axis Endocrinology: hypopituitary adrenal axis - diagram .
  • Natural cortisol levels are suppressed for >8 hours in normal animal.
  • Animals with hyperadrenocorticism show breakthrough of suppression by 8 hours.
    Wider range of degree and duration of suppression in cats than dogs.

Sampling

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Tests

Availability

  • Widely available.

Technician (extrinsic) limitations

  • Must be able to give intravenous injection and collect samples without stressing animal.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMed Resource and PubMed.
  • Boland L A & Barrs V R (2017) Peculiarities of feline hyperadrenocorticism - Update on diagnosis and treatment. J Feline Med Surg 19, 933-947 PubMed.
  • Valentin S Y, Cortright C C, Nelson R W, Pressler B M, Rosenberg D, Moore G E & Scott-Moncrieff J C (2014) Clinical findings, diagnostic test results and treatment outcome in cats with spontaneous hyperadrenocorticism: 30 cases. JVIM 28(2), 481-487 PubMed.
  • Medleau L, Cowan L A, Cornelius L M (1987) The effect of low dose intravenous dexamethasone administration. Res Vet Sci 42, 260-261.
  • Peterson M E, Graves T K (1987) The effects of low dosages of intravenous dexamethasone on serum cortisol concentrations in the normal cat. Am J Vet Res 48, 1719-1724.


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