Felis ISSN 2398-2950

ACTH stimulation test

Contributor(s): David Bruyette, Carmel Mooney, Yvonne McGrotty

Overview

  • Administration of large dose of ACTH ACTH causes maximal release of cortisol by adrenal glands.

Sampling

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Tests

Availability

  • Available at most commercial laboratories.

Validity

Specificity

Sensitivity

  • Sensitivity around 56% (high risk of false negatives) so the ACTH stimulation test is not currently recommended as the initial diagnostic test in cats with suspected HAC.

Result Data

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Further Reading

Publications

Refereed papers

  • Recent references from VetMedResource and PubMed.
  • Boland L A & Barrs V R (2017) Peculiarities of feline hyperadrenocorticism - Update on diagnosis and treatment. J Feline Med Surg 19, 933-947 PubMed.
  • Valentin S Y, Cortright C C, Nelson R W, Pressler B M, Rosenberg D, Moore G E & Scott-Moncrieff J C (2014) Clinical findings, diagnostic test results and treatment outcome in cats with spontaneous hyperadrenocorticism: 30 cases. JVIM 28(2), 481-487 PubMed.
  • Schoeman J P, Evans H J, Childs D & Herrtage M E (2000) Cortisol response to two different doses of intravenous synthetic ACTH (tetracosacrin) in overweight cats. JSAP 41, 552-557.
  • Zobe C A, Refsal K R, Peterson M E, Armstrong P J, Nachreiner R F & Schall W D (1987) Effects of non-adrenal illness on adrenal function in the cat. Am J Vet Res 48, 451-454.


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