Equis ISSN 2398-2977

Warfarin sodium

Introduction

Name

  • Warfarin sodium.

Class of drug

  • Oral anticoagulant.

Uses

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Indications

  • Vascular thrombosis.
  • Navicular disease.

Administration

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Precautions

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Interactions

with other drugs

  • Aspirin - increased risk of bleeding due to antiplatelet effect.
  • Barbiturates, griseofulvin, estrogens, progestogens, phenobarbital and vitamin K - reduced anticoagulant effect.
  • Anabolic steroids, chloramphenicol, cimetidine, erythromycin, ketoconazole, metronidazole, miconazole, nalidixic acid, neomycin, paracetamol (regular treatment with high doses), quinidine, sulfonamides, tamoxifen, tetracyclines, levothyroxine, aspirin, phenylbutazone and possibly other NSAIDs - enhanced anticoagulant effects.
  • Phenytoin - both enhanced and reduced anticoagulant effects.
  • Sucralfate - impaired absorption.

Adverse Reactions

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Further Reading

Publications

Refereed papers

Other sources of information

  • Derived from The Veterinary Formulary (1998) 4th edn. Ed: Bishop Y. British Veterinary Association and Royal Pharmaceutical Society.

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