Equis ISSN 2398-2977

Therapeutics: glucocorticoids

Contributor(s): Sally Anne Argyle, Ruth Morgan

Introduction

  • Glucocorticoids are steroid hormones produced by the adrenal glands.
  • They are controlled by a negative feedback system acting via the pituitary gland, the hypothalamus and the adrenal glands.
  • The most important naturally occurring glucocorticoid receptor present in the cytoplasm of almost all cells in the body.
  • Their actions are wide ranging and are mediated via alteration in protein expression of cells.

Actions of glucocorticoids

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Therapeutic uses for glucocorticoids

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Side effects / contraindications

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Further Reading

Publications

Refereed papers

  • Recent references from PubMed and VetMedResource.
  • Menendez M I, Phelps M A, Hothem E A & Bertone A L (2012) Pharmacokinetics of methylprednisolone acetate after intra-articular administration and subsequent suppression of endogenous hydrocortisone secretion in exercising horses. Am J Vet Res 73 (9), 1453-1461 PubMed.
  • Dauvillier J, Felippe M J B, Lunn D P et al (2011) Effect of long-term fluticasone treatment on immune function in horses with heaves.  J Vet Intern Med 25 (3), 549-557 PubMed.
  • Bailey S R (2010) Corticosteroid-associated laminitis. Vet Clin North Am Eq Pract 26 (2), 277-285 PubMed.
  • Leclere M, Lefebvre-Lavoie J, Beauchamp G & Lavoie J P (2010) Efficacy of oral prednisolone and dexamethasone in horses with recurrent airway obstruction in the presence of continuous antigen exposure. Equine Vet J 42 (4), 316-321 PubMed
  • Goodrich L R & Nixon A J (2006) Medical treatment of osteoarthritis in the horse - a review. Vet J 171 (1), 51-69 PubMed.

Other sources of information

  • Bertone J & Horspool L (2004) Equine Clinical Pharmacology. Saunders Elsevier.


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