Equis ISSN 2398-2977

Eyeball: phthisis bulbi

Contributor(s): Keith Barnett, Paul E Miller, Graham Munroe

Introduction

  • Atrophy or shrinkage of globe.
  • Cause: follows severe intraocular inflammation, infection or trauma.
  • Signs: small, often soft globe with protruding third eyelid and anterior segment changes; visual deficits. Subtle forms often manifested by drooping of the upper eyelid/cilia.
  • Diagnosis: history, signs, histopathology.
  • Treatment: enucleation or chronic topical ophthalmic ointment with periodic irrigation of the conjunctival cul de sac to remove extraneous debris.
  • Prognosis: phthisis bulbi is an end stage condition with no chance of improvement.

Pathogenesis

Etiology

  • Severe intraocular inflammation/infection:
    • Chronic or recurrent uveitis   Uveitis: recurrent  .
    • Blunt ocular trauma.
    • Globe penetration or corneal perforation.
    • Chronic glaucoma.

Pathophysiology

  • Atrophy or shrinkage of the globe following severe infection or intraocular inflammation such as chronic or recurrent uveitis   Uveitis: recurrent  , trauma or perforations.
  • May occur rapidly over several days after the insult, or more often, chronically over weeks to months.

Diagnosis

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Treatment

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Prevention

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Outcomes

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Further Reading

Publications

Refereed papers


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