ISSN 2398-2993      

Oxyclozanide

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Contributor(s):

Rob Kelly

Andrew Forbes

Royal Dick School Veterinary Studies logo


Introduction

Name

  • Oxyclozanide.

Class of drug

  • Salicylanilide.

Description

Chemical name

  • 2,3,5-trichloro-N-(3,5-dichloro-2-hydroxyphenyl)-6-hydroxybenzamide.

Molecular formula

  • C13H6Cl5NO3.

Molecular weight

  • 401.46.

Physical properties

  • Fluid formulation usually a white to yellow color. 
  • Powder formulations, which are not licenced for use in animals, are available usually white in color with a melting point of ~205oC/401oF.

Storage requirements

Uses

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Indications

Administration

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Pharmacokinetics

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Precautions

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Interactions

With other drugs

  • None reported.

With diagnostic tests

  • None reported.

Withdrawal Period

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Adverse Reactions

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Further Reading

Publications

Refereed Papers

  • Recent references from PubMed and VetMedResource.
  • Fairweather I, Brennan G P, Hanna R E B, Robinson M W & Skuce P J (2020) Drug resistance in liver flukes. Int J Parasitol Drugs Drug Resist 12, 39-59 PubMed
  • Howell A K & Williams D J L (2020) The epidemiology and control of liver flukes in cattle and sheep. Vet Clin North Am Food Anim Pract 36 (1), 109-123 PubMed
  • Forbes A B (2018) Rumen fluke: past, present and future. Livestock 23 (5), 227-231.
  • Arafa W M, Shokeir K M, Khateib A M (2015) Comparing an in vivo egg reduction test and in vitro egg hatching assay for different anthelmintics against Fasciola species, in cattle. Vet Parasitol 214 (1-2), 152-158 PubMed
  • Arias M S, Sanchís J, Francisco I et al (2013) The efficacy of four anthelmintics against Calicophoron daubneyi in naturally infected dairy cattle. Vet Parasitol 197 (1-2), 126-129 PubMed
  • Nzalawahe J, Hannah R, Kassuku A A, Stothard J R, Coles G, Eisler M C (2011) Evaluating the effectiveness of trematocides against Fasciola gigantica and amphistomes infections in cattle, using faecal egg count reduction tests in Iringa rural and Arumeru districts, Tanzania. Parasites Vectors 11 (1), 384 VetMedResource.
  • Mitchell G (2002) Update on fasciolosis in cattle and sheep. In Pract 24 (7), 378-385 VetMedResource
  • Coles G C & Stafford K A (2001) Activity of oxyclozanide, nitroxynil, clorsulon and albendazole against adult triclabendazole-resistant Fasciola hepatica. Vet Rec 148 (23), 723-724 VetMedResource
  • Fairweather I & Boray J C (1999) Fasciolicides: efficacy, actions, resistance and its management. Vet J 158 (2), 81-112 PubMed
  • Martin R J (1997) Modes of action of anthelmintic drugs. Vet J 154 (1), 11-34.

Other sources of information

  • Deplazes P, Eckert J, Mathias A, von Samson-Himmelstjerna & Zahner H (2016) Helminths and Principles of Therapy and Control. In: Parasitology in Veterinary Medicine. Wageningen Academic Publishers. pp 175-186, 191-197, 224-254, 287-302, 303-312, 556-572.
  • Taylor M A, Coop R L & Wall R L (2007) Veterinary Helminthology from Cattle, Sheep and Resistance Sections. In: Veterinary Parasitology. 3rd edn. Blackwell Science. pp 51-91, 152-212, 770-775.
  • National Office of Animal Health (NOAH) Compendium of Data Sheets for Animal Medicines. Website: www.noahcompendium.co.uk.
  • The NOAH Compendium. Datasheets of licensed veterinary medicines. Website: www.noahcompendium.co.uk.
  • Veterinary Medicines Directorate (VMD) Adverse Reaction Reporting. Website: www.vmd.defra.gov.uk.
  • Veterinary Medicines Directorate (VMD) Questions and Answers on FDA's Adverse Event Reporting System (FAERS). Website:  www.noahcompendium.co.uk/home.
  • Veterinary Substances Database. Website: http://sitem.herts.ac.uk. Accessed October 23, 2020.

Organisation(s)

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