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  • Cimicoxib.

Class of drug

  • COX-2 inhibitor.



  • Selective inhibitor of cyclooxygenase-2 enzyme (COX-2), member of the coxib class of drugs.


  • Treatment of pain associated with arthritis in dogs.
  • Management of peri-operative pain in orthopedic and soft-tissue procedures in dogs.

Adverse reactions

Other reported reactions

  • Typical side effects associated with NSAIDs are likely to be seen with overdose. Vomiting or other adverse reactions of the gastrointestinal tract are the most common side effects seen with cimicoxib administration, animals generally recover without treatment.
  • In very rare cases, increases in kidney function results (renal biochemistry parameters) can occur.
  • If adverse reactions such as persistent vomiting, repeated diarrhea, blood in the stools, sudden weight loss, loss of appetite, lethargy or worsening of liver or kidney function results occur, use of the product should be discontinued.

Investigation of adverse reaction

  • A veterinary surgeon investigating an adverse reaction should investigate in conjunction with the manufacturer as they will be able to best advise on a logical sequence of steps to undertake. History taking from the owner as to the timing of clincal signs relative to the onset of adverse reaction, other medications/compounds that the animal is being given (prescribed or not) and the potential for an adverse reaction to environmental compounds as vital. Collection of blood samples to measure changes in hematological and biochemical parameters and a careful clinical examination should be carried out. All treatment that is administered should be carefully documented.

Reporting of reactions

  • Suspected adverse reaction reports can be filed by anyone. In practice, most are submitted by veterinary surgeons and pharmaceutical companies. Reports should be sent to the Veterinary Medicines Directorate (VMD) and also to the manufacturer or distributor of the medicine where this is known. Pharamaceutical companies may meet the cose of investigating suspected adverse reactions reported to them
  • For most reactions, a SARSS form (Form MLA 252A) should be completed. Copies can be found in the BSAVA Small Animal Formulary or in the NOAH Datasheet Compendium. Copies can also be downloaded or completed online. If the reaction is a result of the animal being exposed after environmental contamination with a veterinary medicine, then a separate form is used (MLA 1 (A5)).
  • Completed forms should be sent to: The Veterinary Medicines Directorate, FREEPOST KT4503, New Haw, Addlestone, Surrey KT15 3BR, UK.


  • If an animal experiences side effects to cimicoxib manage symptomatically as appropriate and stop administration of cimicoxib. The period of supportive treatment should be adjusted according to the requirements of the individual patient. Provide analgesia with an alternative class of analgesic drug that will not exacerbate the presenting clinical signs.

Antidote for overdose

  • There is no antidote to NSAID overdose.
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