- Pathogenesis : abnormal proteinaceous deposits accumulate within tissues.
- Signs : depend on which tissues are disrupted by amyloid accumulation.
- May be systemic or localized: kidneys often affected , also liver and spleen.
- Treatment : few options: colchicine and dimethyl sulfoxide (DMSO) have been tried.
- Prognosis : usually progressive until death.
- Familial and sporadic forms also occur.
- Dyspnea (if pulmonary thrombosis).
- Hindleg paralysis (if aortic thrombosis).
- Other causes of chronic renal failure .
- Poor; usually progressive deposition. Fibrils are resistant to phagocytosis or proteolysis.
Expected response to treatment
- Improvement in clinical signs.
- Lack of progression of disease.
Reasons for treatment failure
- Disease usually progressive.