- Cause : possibly excessive hormonal trophic factors, eg gastrin → focal, localized, eg pylorus obstruction or diffuse thickening of gastric mucosa. Reaction to foreign body, gastrinoma.
- Signs : vomiting of variable character with or without blood.
- Diagnosis : gastroscopy and histopathology; laparotomy and histopathology. Often normal biopsies with endoscopy. Laprotomy to get submucosa/muscle in biopsy.
- Treatment : treat underlying cause or symptomatic.
- Prognosis : depends on finding and eliminating the underlying cause.
- Variable depending on severity and area affected, ie may require pyloroplasty .
- If associated with familial intestinal disease and renal tubular defect (Basenji), systemic mast cell neoplasia, or gastroma - poor prognosis.
Expected response to treatment
- Control of vomiting with medical and dietary management.
Reasons for treatment failure
- Failure to treat underlying disease.