- Immune-mediated thrombocytopenia (IMTP) is rare and poorly documented in the cat (in contrast to the dog).
- Cause : most cases are likely to be secondary (particularly to FeLV infection and associated neoplasia) rather than primary autoimmune thrombocytopenia (AITP).
- Signs : vague eg anorexia, lethargy.
- Diagnosis : often presumptive, platelet count <50,000, anti-platelet antibody.
- Treatment : treat underlying condition and immunosuppression if required.
- Prognosis : guarded.
Print off the owner factsheet on -Immune mediated thrombocytopenia to give to your client.
- Ecchymotic hemorrhages of retina, iris and sclera.
- Petechial hemorrhage of mucous membranes: mouth, sclera.
- Petechial hemorrhages on skin - but coat may need to be clipped to see these.
Differential diagnosisOther causes of thrombocytopenia .
- Disseminated intravascular coagulation .
- Bone marrow suppression by FeLV [Feline leukemia virus disease] , FIE [Feline panleucopenia virus disease] , myelophthisis, ehrlichiosis (rare in cat).
- Splenic sequestration in hypersplenism.
- Other bleeding disorders.
- Must be guarded as underlying disease is often severe.
- If underlying case can be identified and treated or response to treatment is rapid the prognosis may be favorable.
Expected response to treatment
- Cessation of spontaneous bleeding if present.
- Increasing platelet count.
Reasons for treatment failure
- Underlying disease not diagnosed or treated adequately.
- Therapy not sufficiently aggressive.