Name
- Selamectin.
Class of drug
- Avermectin parasiticide.
Uses
Action
- Selamectin is a semi-synthetic avermectin.
- It induces neuromuscular paralysis and/or death in susceptible invertebrate parasites by binding to and opening glutamate-gated chloride channels (glutamate agonists).
Indications
Dogs, cats- Treatment and prevention of flea infestation caused by Ctenocephalides spp
. - As part of strategy for treatment of flea allergy dermatitis .
- Prevention of heartworm disease caused by Dirofilaria immitis with monthly administrations.
Dogs
- Treatment of sarcoptic mange caused by Sarcoptes scabiei .
- Treatment of adult intestinal roundworms ( Toxocara canis ).
- Control of tick ( Dermacentor variabilis ) infestations.
Cats
- Treatment of ear mites ( Otodectes cynotis ).
- Treatment of adult intestinal roundworms ( Toxocara cati ).
- Treatment of adult intestinal hookworms ( Ancylostoma tubaeforme ).
Adverse reactions
Effects of overdosage
- Accidental ingestion of the recommended topical dose may result in hypersalivation or vomiting in cats.
Other reported reactions
- In cats, occasional mild transient hair loss at site of application. In a small proportion of these cases, may also have transient focal irritation. These are normally self-resolving, but symptomatic therapy may be useful in some circumstances.
- Local temporary clumping of the hair at the application site and/or the appearance of a small quantity of white powder. This is normal and will disappear within 24 hours of administration.
- If animal licks site of application, a brief period of hypersalivation may rarely be observed in cats.
