Benazepril

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Sections available in full article Name, Class of drug, Description, Uses, Administration, Routes of administration, Dosage, Timing of administration, Pharmocokinetics, Normal, Physiological, variations, Precautions, Contra-indications, Use with care, Interactions, Adverse reactions, Sources, Publications, Vetstream contributor(s),
Contributors Ms Yolande Bishop BVMS MRCVS
Dr Mark Rishniw BVSc MS DipACVIM
Synonyms Fortekor 5, Fortekor 20, Lotensin

Name

  • Benazepril.

Class of drug

  • Angiotensin converting enzyme (ACE) inhibitor  ACE inhibitors: overview  .

Uses

Action

  • Rapid absorption from the gastrointestinal tract following oral administration; benazepril is then hydrolyzed by the liver to benazeprilat, a highly specific and potent angiotensin converting enzyme (ACE) inhibitor.
  • ACE inhibition reduces conversion of inactive angiotensin I into angiotensin II, thus reducing angiotensin II-mediated effects (vasoconstriction of arteries and veins and renal sodium and water retention).
  • Lowers blood pressure and cardiac volume loading in heart failure.
  • Significantly extends lifespan and improves clinical signs in congestive heart failure (reduced coughing and quality of life improved).
  • A single dose produces significant inhibition of plasma ACE for more than 24 hours.
  • In cats with renal disease it reduces protein loss in urine and lowers blood pressure.

Indications

  • Treatment of congestive heart failure.
  • Treatment of hypertension  Hypertension  .
  • May be of benefit in certain cases of renal insufficiency. Benazeprilat has significant hepatic metabolism.

Adverse reactions

Effects of overdosage

  • May reduce RBC counts at high dose.

Other reported reactions

  • Hypotension (weakness, disorientation).
  • Hyperkalemia.
  • Renal impairment.
  • Increased appetite and weight gain in cats.

Investigation of adverse reaction

  • [K+].
  • BUN/creatinine.

Treatment

  • Reduce dose if signs of hypotension.
  • Reduce dose if signs of azotemia.

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