Quinidine

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Precautions, Interactions, Adverse reactions, Sources, Publications,
Contributors

Name

  • Quinidine.

Class of drug

  • Class 1a antiarrhythmic agent.

Uses

Action

  • Depresses conduction velocity, myocardial contractility and excitability, and prolongs the refractory period. Thus, conduction time is increased and the re-entry phenomenon is prevented.
  • In addition, quinidine has indirect antimuscarinic effects, decreases vagal tone and may improve conduction at the AV junction.

Indications

  • It is used in the management of ventricular arrhythmias (VPC's)  Ventricular premature contraction  , refractory supraventricular tachycardias (with caution) and acute atrial fibrillation .

Adverse reactions

Other reported reactions

  • Weakness.
  • Vomiting.
  • Diarrhea.
  • Hypotension (especially with too rapid IV administration).
  • Widening of QRS and QT interval, AV block and decreased contractility.

Investigation of adverse reaction

  • Patients exhibiting signs of toxicity or a lack of response should have their serum levels measured. Serum therapeutic levels are thought to range from 0.0025-0.005 mg/ml in dogs. Toxic effects are not usually evident when serum levels are less than 0.01mg/ml.

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