Name
- Prednisolone.
Class of drug
- Corticosteroid.
Uses
Action
- A synthetic corticosteroid which is used as an anti-inflammatory and immunosuppressive drug and anti-fibrotic (reduces collagen production).
- Has approximately 4 times the anti-inflammatory potency and 1/2 the relative mineralocorticoid potency of hydrocortisone
. - Like prednisone and methylprednisone , is considered to be an intermediate acting glucocorticoid and is suitable for alternate day use.
Indications
- Anti-inflammatory.
- Immunosuppression.
- Anti-fibrotic.
- Aid in management of hypoadrenocorticism .
Adverse reactions
Other reported reactions
- A single dose may suppress adrenal gland function for up to 1 week.
- Chronic use may lead to the development of iatrogenic hyperadrenocorticism .
- Elevated liver enzymes.
- Weight loss.
- Poluria/polydipsia.
- Vomiting and diarrhea.
- Thinning of skin and poor wound healing.
- Immunosupression.
- Gastric or intestinal ulceration.
Increased risk associated with concurrent use of NSAIDs.
