Phenylbutazone

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Sections available in full article Name, Class of drug, Uses, Administration, Routes of administration, Dosage, Precautions, Contra-indications, Interactions, Adverse reactions, Sources, Publications, Vetstream contributor(s),
Contributors Dr Kyle Braund BVSc MVSc PhD FRCVS DipACVIM

Name

  • Phenylbutazone.

Class of drug

  • Non-steroidal anti-inflammatory drug (NSAID)  Therapeutics: musculoskeletal system  .

Uses

Action

  • A non-steroidal anti-inflammatory drug which inhibits cyclooxygenase-1 enzyme thereby limiting prostaglandin production.
  • NSAIDs have antipyretic, analgesic  Analgesia: overview  , anti-inflammatory and antiplatelet effects.

Indications

  • Control of mild to moderate pain and inflammation in osteoarthritic conditions  Degenerative joint disease  .

Adverse reactions

Effects of overdosage

  • Severe toxicity (usually with an acute overdose) may present with vomiting, pyrexia, metabolic acidosis, depression, coma, seizures and GI bleeding.

Other reported reactions

  • Gastrointestinal irritation and ulceration.
  • Renal papillary necrosis ( renal failure), particularly if hypotension, dehydration or other nephrotoxic drugs are present.
  • Nausea, vomiting.
  • Diarrhea.
  • Hepatotoxicity (cholestatic and parenchymal damage).
  • Agranulocytosis.
  • Bone marrow suppression (including aplastic anemia).
  • Fluid retention which may precipitate cardiac failure.

Antidote for overdose

  • Empty gut.
  • Treat acidosis.
  • Alkalinize urine with sodium bicarbonate  Sodium bicarbonate  .
  • Supportive therapy.

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