Hydralazine

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Sections available in full article Name, Class of drug, Description, Uses, Administration, Do not mix with, Routes of administration, Dosage, Precautions, Use with care, Interactions, Adverse reactions, Sources, Publications, Vetstream contributor(s),
Contributors Dr Mark Rishniw BVSc MS DipACVIM

Name

  • Hydralazine.

Class of drug

  • Peripheral vasodilator.

Uses

Action

  • Acts directly on arteriolar smooth muscle causing vasodilation, possibly by altering calcium handling by vascular smooth muscle cells.
  • Can decrease systemic vascular resistance to about 50% of baseline value.
  • Reduces afterload.
  • Rarely used in cats for heart failure.

Indications

  • CHF due to valve disease. Does not benefit patients with myocardial failure.

Adverse reactions

Other reported reactions

  • Severe hypotension (monitor and adjust doses as necessary).
  • Anorexia and vomiting (commonly seen in cats).
  • Reflex sinus tachycardia.

Treatment

Tachycardia
  • Digoxin therapy or beta-blockers.

Antidote for overdose

  • Pressor support (fluids).

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