Factor XII deficiency

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Sections available in full article Introduction, Presenting signs, Sex predisposition, Special risks (e.g. anesthetic), Pathogenesis, Predisposing factors, Pathophysiology, Epidemiology (population dynamics), Diagnosis, Presenting problems, Diagnostic investigation, Treatment, Initial symptomatic treatment, Monitoring, Sequelae, Prognosis, Reasons for treatment failure, Sources, Publications, Vetstream contributor(s),
Contributors Mr David Godfrey BVetMed CertSAD CertSAM DipABVP(Feline practice) CBiol FSB FRCVS
Dr Janet Littlewood BVSc MA PhD DVD DVR MRCVS
Dr Severine Tasker BSc BVSc DSAM CertSAM DipECVIM-ca MRCVS
Synonyms Hageman factor deficiency

Introduction

  • Factor XII is also known as Hageman factor.
  • Factor XII deficiency is the most common congenital coagulopathy recognized in the cat.
  • Cause : congenital deficiency of Factor XII.
  • Signs : asymptomatic unless combined with another disease process.
  • It has been reported in conjunction with other hemostatic abnormalities in which case there are clinical signs.
  • Diagnosis : it is suspected when activated partial thromboplastin time (APTT) is prolonged especially if the cat has no clinical hemostatic problem.
  • Treatment : none required.
  • Prognosis : excellent.

Sequelae

Prognosis

  • Excellent.

Reasons for treatment failure

  • Incorrect diagnosis.

Sources

Publications

Refereed papers

  • Recent references fromPubMed.
  • Brooks M & DeWilde L (2006)Feline Factor XII Deficiency.Comp Contin Educ Pract Vet28, 148-155.
  • Hart S W & Nolte I (1994)Hemostatic disorders in Feline Immunodeficiency Virus-seropositive cats.J Vet Intern Med8, 355.
  • Littlewood J D & Evans R J (1990)A combined deficiency of factor VIII and contact activation defect in a family of cats.British Vet J146, 30-35.
  • Dillon A R & Boudreaux M K (1988)Combined factors IX and XII deficiencies in a family of cats.JAVMA193, 833.
  • Hoffman L & Sperling K (1986)Acquired hemostatic problems in a cat with factor XII deficiency.Feline Practice16, 25.

Other sources of information

  • Baldwin C J & Cowell (1997)Inherited Coagulopathies.In:Consultations in Feline Internal Medicine. 3rd edn. Ed: J R August. Philadelphia: W B Saunders. pp 488.

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