Lung: pulmonary neoplasia

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Sections available in full article Introduction, Presenting signs, Age predisposition, Cost considerations, Special risks (e.g. anesthetic), Pathogenesis, Pathophysiology, Timecourse (incubation, duration), Diagnosis, Presenting problems, Client history, Clinical signs, Diagnostic investigation, Confirmation of diagnosis, Gross autopsy findings, Differential diagnosis, Treatment, Initial symptomatic treatment, Standard treatment, Monitoring, Sequelae, Prognosis, Reasons for treatment failure, Sources, Publications, Vetstream contributor(s),
Contributors Dr Philip K Nicholls BVSc BSc PhD MRCVS FRCPath
Dr Irene Rochlitz BVSc MSc PhD

Introduction

  • Neoplasia arising directly from bronchopulmonary tissue, or as a result of metastasis.
    Primary tumors
  • <0.5% of feline neoplasms. Most are malignant:
    • Papillary adenocarcinoma.
    • Bronchoalveolar adenocarcinoma.
    • Squamous cell carcinoma.
    • Bronchial gland carcinoma.
    • Adenosquamous carcinoma.

    Secondary tumors:
  • Mammary adenocarcinoma  Adenoma  adenocarcinoma  .
  • Squamous cell carcinoma  Squamous cell carcinoma  .
  • Lymphoma  Lymphoma  .
  • Osteosarcoma .
  • Signs : variable, tachypnea, dyspnea, lethargy, cachexia, lameness, vomiting/regurgitation, hemoptysis, bronchopneumonia, persistent cough.
  • Diagnosis : history, clinical signs, radiography, bronchoscopy, histopathology.
  • Treatment : surgical excision if possible with isolated primary tumor. Chemotherapy or palliative treatment.
  • Prognosis : generally poor, but good if successful excision of isolated or benign neoplasm.

Diagnosis

Clinical signs

  • Tachypnea.
  • Expiratory dyspnea.
  • Coughing.
  • Lameness/pain: associated with distal bony metastases or hypertrophic pulmonary osteopathy.
  • Mammary lesion.
  • Pyrexia.
  • Dullness on thoracic percussion, associated with pleural effusion or large mass.

Diagnosis

Differential diagnosis

  • Chronic bronchial disease  Chronic bronchitis  .
  • Pleural effusion  Pleural effusion  .
  • Pneumonia  Pneumonia  .
  • Bronchiectasis.
  • Pulmonary hemorrhage  Lung: pulmonary hemorrhage  .
  • Tuberculosis (respiratory form)  Mycobacterium tuberculosis  .

Sequelae

Prognosis

  • Generally poor with most primary neoplasms. Depends on tumor type, size, site, involvement of lymph nodes and metastasis.
  • Metastatic disease commonly seen in many sites, including regional lymph nodes, mediastinum, pleura, heart, spleen and appendicular skeleton.
  • Good if complete excision of benign primary tumor.

Reasons for treatment failure

  • Inoperability.
  • Metastasis.

Sources

Publications

Refereed papers

  • Hahn K Aet al(1999)Primary lung tumors in cats - 86 cases (1979-1994).JAVMA211(10), 1257-1260.
  • Barr I F, Gruffydd-Jones T J, Brown P Jet al(1987)Primary lung tumors in the cat.JSAP28, 1115-1125.

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