Pelger Huet anomaly

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Sections available in full article Introduction, Presenting signs, Age predisposition, Breed predisposition, Pathogenesis, Etiology, Pathophysiology, Timecourse (incubation, duration), Diagnosis, Client history, Clinical signs, Diagnostic investigation, Differential diagnosis, Treatment, Initial symptomatic treatment, Prevention, Group eradication, Sequelae, Prognosis, Sources, Publications, Vetstream contributor(s),
Contributors Ms Catherine Fraser BVSc CertVD MRCVS
Prof Michael Day BSc BVMS(Hons) PhD DSc DiplECVP FASM FRCPath FRCVS

Introduction

  • Extremely rare.
  • Cause : congenital hereditary disorder of leukocyte development.
  • Signs : may be evidence of low-grade infection.
  • Diagnosis : often incidental finding of apparent continual left shift despite animal appearing clinically normal.
  • Treatment : none, supportive care only if evidence of infection.
  • Prognosis : survival times not reported but animals probably can live relatively normal lives.

Diagnosis

Clinical signs

  • No clinical signs specific to disease.
  • Homozygous form has been reported in association with chondrodysplasia  Chondrodysplasia  .

Diagnosis

Differential diagnosis

  • Shift to the left associated with active immune response.
  • Feline leukemia virus infection  Feline leukemia virus disease  .
  • Pseudo Pelger-Huet cells may be found in other disease states:
    • Severe infection.
    • Leukemia  Leukemia  .
    • Drug therapy, eg sulfonamides  Sulfadiazine  (in people).

Sequelae

Prognosis

  • Prognosis may be quite good as many individuals reach adulthood without diagnosis.

Sources

Publications

Refereed papers

  • Latimer K S, Rowland G N & Mahaffey M B (1988)Homozygous Pelger-Huet anomaly and chondrodysplasia in a stillborn kitten.Vet Pathol25, 325-328.
  • Guildford W G (1987)Primary immunodeficiency diseases of dogs and cats.Comp Cont Educ Prac Vet9, 641-50. (Useful review of feline immunodeficiency.)
  • Latimer K S, Rakich P M & Thompson D F (1985)Pelger-Huet anomaly in cats.Vet Pathol22, 370-374.
  • Weber S E, Evans D A & Feldman B F (1981).Pelger-Huet anomaly of granulocytic leukocytes in two feline littermates.Feline Practice11, 44-47. (Original report of the anomaly in cats.)

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