Feline leukemia virus
Buy now to access the full article, existing subscribers login
Classification
Taxonomy
- Family: Retroviridae.
- Group: Gammaretrovirus.
- Subtypes A ,B, C, and T determined by host cell spectrum.
Etymology
- Retro because the viral RNA is reverse transcribed into DNA (proviral DNA).
Distribution
- Worldwide.
- 0.5-1% prevalence in healthy cats in the UK.
- Higher prevalence in sick cats.
- In multicat households with endemic FeLV, 30-40% will develop persistent viremia.
Significance
- 3 disease syndromes:
- Immunosuppression.
- Proliferative (neoplasia, leukemia).
- Degenerative (anemia, leukopenia).
- In cat:
- Immunosuppressive.
- Oncogenic, causing T-cell lymphosarcomas
.
- Reproductive failure: abortion, failure to conceive.
- Anemia
.
- Enteritis.
- In human:
- Not zoonotic (Nowotny et al , 1995).
- Other species:
- Does not infect non-felidae.
Sources
Publications
- Recent references fromPubMed.
- Lutz H, Addie A, Belak S, Boucraut-Baralon C, Egberink H, Frymus T, Gruffydd-Jones T, Hartmann K, Hosie M J, Lloret A, Marsilio F, Pennisi M G, Radford A D, Thiry E, Truyen U, Horzinek M C (2009)Feline leukaemia. ABCD guidelines on prevention and management.J Feline Med Surg11(7), 565-574PubMed.
- Muirden A (2002)Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus and feline coronavirus in stray cats sent to an RSPCA hospital.Vet Rec.150(20), 621-625.
- Dawson S, Gaskell R & Jarrett O S (1999)Vaccination in cats - an update.In Practice21, 71-74.
- Nowotny N, Uthman A, Haas O A, Borkhardt A, Lechner K, Egberink H F, Mostl K and Horzinek M C (1995)Is it possible to catch leukaemia from a cat?The Lancet346(22), 252-253.
- Squires R & Gorman N T (1990)Antineoplastic chemotherapy in cats.In Practice12(3), 101-111.
- Pacitti A M, Jarrett O, Hay D (1986)Transmission of feline leukaemia virus in the milk of a non-viremic cat.Vet Rec118, 381.
Sample content only, to unlock the full article
login or buy now